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Vinblastin 10mg/vial Injection
Vinblastin 10mg/vial Injection
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ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
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Vinblastin

Injection - (10mg/vial)
arogga-brand
City Overseas
Generic: Vinblastine
Out of Stock
Currently unavailable, please request or choose another variant.
৳ 654.48
৳ 720
9% OFF
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Vinblastin. Please consult your doctor.
CONSULT YOUR DOCTOR
Vinblastin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Vinblastin is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Vinblastin may cause side effects which could affect your ability to drive.
SAFE IF PRESCRIBED
Vinblastin is safe to use in patients with kidney disease. No dose adjustment of Vinblastin is recommended. However, talk to your doctor if you have any underlying kidney disease.
CAUTION
Vinblastin should be used with caution in patients with liver disease. Dose adjustment of Vinblastin may be needed. Please consult your doctor. Use of Vinblastin may not be advised in patients with severe liver disease.

Medicine Overview of Vinblastin 10mg/vial Injection

Introduction
Vinblastin is an anti-cancer medication used in the treatment of breast cancer, kidney cancer, Hodgkin’s disease, and Non-Hodgkin's lymphoma. Vinblastin is given as an injection into the vein under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months...
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Uses of Vinblastin
  • Breast cancer
  • Kidney cancer
  • Hodgkin’s disease
  • Non-Hodgkin's lymphoma
Side effects of Vinblastin
Common
  • Nausea
  • Vomiting
  • Decreased appetite
  • Decreased white blood cell count
  • Diarrhea
How to use Vinblastin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Vinblastin works
Vinblastin blocks replication of genetic material (DNA) in the cancer cells. Thus it stops the growth and multiplication of cancer cells.
Quick Tips
  • In males vinblastine may cause aspermia (lack of semen causing infertility); in females vinblastine may cause amenorrhea (absence of menstruation), which may recover after some duration.
  • Take precautions while taking vinblastine as it may cause inflammation of mouth and lips (stomatitis) and neurological toxicity.
  • Avoid even accidental contamination of eyes with vinblastine, as it may cause severe irritation.
  • Vinblastine may cause acute kidney disease (nephropathy) related to uric acid level.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
Brief Description
Indication
Histiocytic lymphoma, Hodgkin's disease, Kaposi's sarcoma, Letterer-Siwe disease, Lymphocytic lymphoma, Mycosis fungoides, Testicular cancer
Administration
IV Preparation IV push 1 mg/mL (dose/syringe); max syringe size for IVP is a 30 mL syringe & syringe should be <75% full Powder: reconstitute w/ 10 mL NS or bacteriostatic NS to obtain 1 mg/mL soln Continuous infusion: 250-1000 mL D5W or NS (dose)
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Adult Dose
Intravenous Cancers Testicular CA, Squamous cell CA of head & neck, Hodgkin's Dz, Kaposi's sarcoma; histiocytic lymphoma, mycosis fungoides, & Letterer-Siwe disease (histiocytosis X) General Dosing Ranges 3.7-18 mg/sq.meter/day IV q7-10d 1st dose 3.7 mg/sq.meter/day IV Incr by 1.85 mg/sq.meter qweek until WBC equal 3000/cu.mm NMT 18.5 mg/sq.meter Hepatic impairment Decrease dose by half if bilirubin >3 mg/dL [>51 umol/L]
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Child Dose
Intravenous Cancers Testicular CA, Squamous cell carcinoma CA of head & neck, Hodgkin's Dz, Kaposi's sarcoma; histiocytic lymphoma, mycosis fungoides, & Letterer-Siwe disease (histiocytosis X) General dosing ranges 2.5- 12.5 mg/sq meter IV q7-10d 1st dose 2.5 mg/sq.meter IV Incr by 1.25 mg/sq.meter qWeek until WBC = 3000/cu.mm No more than 12.5 mg/sq.meter
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Contraindication
Severe bone marrow suppression; presence of bacterial infection; maglignant cell infiltration of bone marrow; Inj into extremity with poor circulation; porphyria; granulocytopenia. Elderly with cachexia or extreme skin ulcerations. Pregnancy; lactation. Intrathecal use may result in death.
Mode of Action
Vinblastine is M phase specific. It binds to microtubular proteins and arrests mitosis at the metaphase by disrupting mitotic spindle formation. It blocks glutamic acid utilization, thus inhibiting purine synthesis, the citric acid cycle, and the formation of urea. It may also interfere with nucleic acid and protein synthesis.
Precaution
Hepatic impairment; neurotoxicity; ischemic heart disease; preexisting pulmonary dysfunction; extravasation may cause tissue damage and pain. Discontinue immediately if extravasation occurs, with local Inj of hyaluronidase and local heat application to decrease discomfort and risk of cellulitis; remaining Inj to be injected into another vein. Routine prophylaxis against constipation recommended especially in high doses. Nadir in leukocyte count occur 4-10 days after vinblastine admin; recovery observed 7-14 days after treatment. Lactation: not known if excreted in breast milk, do not nurse
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Side Effect
1-10% Anemia,Leukopenia,Myelosuppression,Alopecia Frequency Not Defined Peripheral neuropathy,Hypertension,Bronchospasm,Nausea,Vomiting,Anorexia,Diarrhea,Constipation,Paralytic ileus,Jaw pain,Aspermia,Amenorrhea
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Interaction
Possible increase in vinblastine levels with aprepitant. Reduced vinblastine metabolism with miconazole. Variable interactions with phenytoin, monitor serum phenytoin levels. Reduced immune response with vaccines. Additive myelotoxicity with zidovudine. Concurrent admin of vinblastine with CYP3A inhibitors may cause an earlier onset and/or an increased severity of side effects. Potentially Fatal: Increased toxicity of vinblastine with erythromycin. Increased neurotoxicity and myelotoxicity with azole antifungals e.g. itraconazole and posaconazole. Increased risk of severe neutropenia with ritonavir. Increased risk of acute pulmonary toxicity with mitomycin. Increased toxicity when ganciclovir is given with, immediately before or after vinblastine.
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ব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
Register
0 People recently viewed this

Vinblastin

Injection - (10mg/vial)
arogga-brand
City Overseas
Generic: Vinblastine
Out of Stock
Currently unavailable, please request or choose another variant.
৳ 654.48
৳ 720
9% OFF

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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.